How inflammation and stress affect brain function related to mood disorders
Peripheral Inflammation and Stress Drive Ventral Striatal Maladaptations
This study is looking at how inflammation and stress affect the part of the brain that controls feelings of pleasure and discomfort, especially in people with conditions like inflammatory bowel disease, to better understand how these factors can lead to issues like depression and anxiety.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-11062358 on NIH RePORTER |
What this research studies
This research investigates the impact of peripheral inflammation and stress on the brain's reward and aversion systems, particularly focusing on the ventral striatum. It aims to understand how these factors contribute to mental health issues like depression and anxiety, which are often exacerbated by chronic conditions such as inflammatory bowel disease. By examining the underlying brain circuitry and signaling pathways, the study seeks to uncover the mechanisms that lead to maladaptive behaviors in response to stress and inflammation. Patients may be involved in assessments that explore their neurobehavioral responses and the effects of inflammation on their mental health.
Who could benefit from this research
Good fit: Ideal candidates for participation are adults over 21 years old who experience anxiety or depression, particularly those with chronic inflammatory conditions.
Not a fit: Patients who do not have mood disorders or chronic inflammatory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for mood disorders linked to inflammation and stress.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between inflammation and mental health, suggesting that this approach could yield valuable insights.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Bibb, James a — University of Arizona
- Study coordinator: Bibb, James a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.