How inflammation affects the risk of HIV infection based on genetic differences
The push and pull of inflammation on HIV susceptibility: impact of host variation in CD101 and AXL
This study is looking at how certain genes might affect why some people are more likely to get HIV-1 than others, even if they have the same level of exposure, and it aims to find new ways to help prevent the infection by analyzing blood samples and immune responses from participants.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10911799 on NIH RePORTER |
What this research studies
This research investigates the biological mechanisms that influence the risk of acquiring HIV-1, particularly focusing on genetic variations in the CD101 and AXL genes. By examining how these genes affect inflammation and immune responses, the study aims to understand why some individuals are more susceptible to HIV despite similar exposure levels. The research involves analyzing blood samples and immune cell responses from participants to identify patterns that could lead to new prevention strategies. Ultimately, the goal is to uncover insights that could help develop interventions to reduce the risk of HIV infection.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals with documented high exposure to HIV-1, especially those with varying outcomes of infection.
Not a fit: Patients who are not at risk of HIV infection or those who are already living with HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing HIV infection, particularly for individuals at high risk.
How similar studies have performed: Previous research has shown promising results in understanding genetic factors related to HIV susceptibility, indicating that this approach has potential for success.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Lingappa, Jairam Rao — University of Washington
- Study coordinator: Lingappa, Jairam Rao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.