How inflammation affects the evolution of JAK2 mutant blood cells
Effect of inflammation on JAK2 mutant evolution in the hematopoietic system: mathematical models and experiments
This study is looking at how inflammation affects the growth of certain cancer cells in people with myeloproliferative neoplasms (MPN), with the hope of finding new ways to slow down or prevent the disease from getting worse.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11075258 on NIH RePORTER |
What this research studies
This research investigates how inflammation influences the growth of JAK2 mutant cells in patients with myeloproliferative neoplasms (MPN), a type of blood cancer. By using mathematical models and experimental approaches, the study aims to understand the relationship between inflammation and the progression of MPN, particularly how it may lead to more aggressive forms of the disease like myelofibrosis and acute myeloid leukemia. The goal is to explore new treatment strategies that could alter the behavior of these mutant cells and potentially delay or prevent disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with early-stage myeloproliferative neoplasms who have the JAK2V617F mutation.
Not a fit: Patients with late-stage myeloproliferative neoplasms or those without the JAK2V617F mutation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that slow down or halt the progression of myeloproliferative neoplasms in patients.
How similar studies have performed: Preliminary studies have shown promising results regarding the impact of inflammation on JAK2 mutant cells, suggesting that this approach could be a novel treatment strategy.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Fleischman, Angela Goffredo — University of California-Irvine
- Study coordinator: Fleischman, Angela Goffredo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.