How inflammation affects prostate stem cells in adults
Impact of Inflammation on Adult Prostate Stem Cells
This study is looking at how inflammation might cause prostate stem cells to grow too much, which can lead to benign prostatic hyperplasia (BPH), and it hopes to find new ways to help manage this condition for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project ID | NIH-10655549 on NIH RePORTER |
What this research studies
This research investigates the role of inflammation in the growth of prostate stem cells, particularly focusing on benign prostatic hyperplasia (BPH). It aims to understand how chronic inflammation contributes to the uncontrolled proliferation of prostate epithelial cells, which can lead to BPH. By examining the pathways that regulate this process, the study seeks to identify potential targets for new treatments that could prevent or reduce prostate enlargement. Patients may benefit from insights that could lead to innovative therapies for managing BPH.
Who could benefit from this research
Good fit: Ideal candidates for this research are adult males experiencing symptoms of benign prostatic hyperplasia or those at risk for developing this condition.
Not a fit: Patients who do not have benign prostatic hyperplasia or related prostate conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively manage or prevent benign prostatic hyperplasia.
How similar studies have performed: Previous research has shown that targeting inflammation can be effective in managing other conditions, suggesting potential success for similar approaches in this study.
Where this research is happening
West Lafayette, United States
- Purdue University — West Lafayette, United States (Active)
Researchers
- Principal investigator: Ratliff, Timothy L. — Purdue University
- Study coordinator: Ratliff, Timothy L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.