How inflammation affects memory and thinking in people with rheumatoid arthritis
Role of Systemic Inflammation in Cognitive Decline: Rheumatoid Arthritis as a Prototype
This study is looking at how long-term inflammation from rheumatoid arthritis might affect memory and thinking skills in older adults, and it will compare those with the condition to those without to see if certain medications can help protect against dementia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10870025 on NIH RePORTER |
What this research studies
This research investigates the connection between systemic inflammation and cognitive decline, using rheumatoid arthritis as a model. It aims to understand how chronic inflammation impacts memory and thinking abilities, particularly in older adults. By comparing patients with rheumatoid arthritis to those without, the study will assess the risk of developing dementia and the potential protective effects of anti-rheumatic medications. The research will involve analyzing existing patient data and cognitive assessments over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults diagnosed with rheumatoid arthritis who are at risk for cognitive decline.
Not a fit: Patients without rheumatoid arthritis or those with other non-inflammatory causes of cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cognitive decline in patients with rheumatoid arthritis and potentially other inflammatory conditions.
How similar studies have performed: Previous research has indicated a link between inflammation and cognitive decline, suggesting that this approach could yield valuable insights.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Myasoedova, Elena — Mayo Clinic Rochester
- Study coordinator: Myasoedova, Elena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.