How inflammation affects lung damage after TB in people with and without HIV
Interleukin-6 signaling, lung injury, and post-TB lung disease in TB-HIV
This project looks at whether an immune signal called interleukin-6 is linked to lung injury and long-term breathing problems in adults treated for pulmonary TB, comparing people who do and do not have HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11195552 on NIH RePORTER |
What this research studies
If you join, you would have regular lung function tests, symptom and functional assessments, and blood samples taken during TB treatment and for months afterward. The team will compare people living with HIV to similar people without HIV using the same tests and follow-up schedule. They will measure interleukin-6 signaling and related markers to see how immune activity relates to lung damage and recovery. Results will come from sites in the RePORT-India consortium and will follow standardized protocols so findings can be compared across participants.
Who could benefit from this research
Good fit: Adults with drug-sensitive pulmonary TB, especially those living with HIV, who can attend clinic visits for lung testing and blood draws during and after TB treatment are the ideal candidates.
Not a fit: Children, people with drug-resistant TB, or anyone unable to attend clinic follow-ups or provide blood samples are unlikely to benefit from participating in this project.
Why it matters
Potential benefit: If successful, the work could reveal targets to help prevent or reduce long-term lung damage after TB, especially for people living with HIV.
How similar studies have performed: Prior research has linked inflammation and IL-6 to lung injury, but there are currently no proven interventions to prevent post-TB lung disease, so this work builds on existing biology while exploring new clinical implications.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Gupte, Akshay Nitin — Boston University Medical Campus
- Study coordinator: Gupte, Akshay Nitin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.