How inflammation affects immune cell function in Crohn's disease
Inflammatory cascades disrupt Treg function through epigenetic mechanisms
This study is looking at how inflammation affects certain immune cells in people with Crohn's disease, with the goal of finding new ways to help these cells work better and improve treatment options for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project ID | NIH-11306803 on NIH RePORTER |
What this research studies
This research investigates how inflammation disrupts the function of specific immune cells known as T regulatory cells in patients with Crohn's disease. It focuses on understanding the epigenetic mechanisms that lead to the activation of pro-inflammatory pathways in these cells, which are typically responsible for regulating immune responses. By examining the genetic and molecular changes in these cells, the research aims to identify potential therapeutic strategies to restore their normal function and improve patient outcomes. The study will involve laboratory analyses and may lead to new treatment options for managing Crohn's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Crohn's disease who are experiencing ongoing inflammation and immune dysregulation.
Not a fit: Patients with Crohn's disease who are in remission or do not exhibit significant immune dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that restore the normal function of immune cells in Crohn's disease, potentially improving disease management and patient quality of life.
How similar studies have performed: Other research has shown promising results in understanding immune cell function in inflammatory diseases, suggesting that this approach may yield valuable insights and therapeutic options.
Where this research is happening
Scottsdale, United States
- Mayo Clinic Arizona — Scottsdale, United States (Active)
Researchers
- Principal investigator: Faubion, William a — Mayo Clinic Arizona
- Study coordinator: Faubion, William a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.