How inflammation affects blood cell development and disease in chronic myelomonocytic leukemia
The impact of inflammation on HSPC composition and disease progression in chronic myelomonocytic leukemia
This study is looking at how inflammation affects chronic myelomonocytic leukemia (CMML) and why some patients might see their condition get worse or change into a different type of leukemia, with the hope of finding better ways to manage the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11036287 on NIH RePORTER |
What this research studies
This research investigates the role of inflammation in the progression of chronic myelomonocytic leukemia (CMML), a serious blood cancer. It focuses on how inflammatory conditions can influence the composition of hematopoietic stem and progenitor cells, which are crucial for blood cell formation. By studying these changes, researchers aim to understand why some patients experience a worsening of their condition or transformation into acute myeloid leukemia (AML). The approach includes analyzing patient samples and using preclinical models to replicate findings, which could lead to new insights into disease management.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with chronic myelomonocytic leukemia, particularly those experiencing disease progression.
Not a fit: Patients with other types of leukemia or those who are asymptomatic without a diagnosis of CMML may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for monitoring and treating patients with chronic myelomonocytic leukemia.
How similar studies have performed: Other research has shown promising results in understanding the role of inflammation in blood cancers, suggesting that this approach could yield valuable insights.
Where this research is happening
Tampa, United States
- H. Lee Moffitt Cancer Ctr & Res Inst — Tampa, United States (Active)
Researchers
- Principal investigator: Padron, Eric — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Padron, Eric
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.