How inflamed fat affects exercise response in older adults
Official title: Mechanisms of Anabolic Resistance in Older Humans
Funded at Mayo Clinic Rochester · NIH-10978966 · Data updated 2026-11-12
This study is looking at how inflammation in body fat might make it harder for older adults to benefit from exercise, and it aims to find ways to help them get better results from their workouts.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $673,650 |
| NIH project number | 1R01AG084733-01A1 |
| Project ID | NIH-10978966 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing reduced exercise capacity or muscle function.
✕Less likely to help
Patients who are younger or do not have issues related to muscle function or exercise response may not benefit from this research.
What this research studies
This research investigates how inflamed adipose tissue in older adults may hinder their ability to respond to exercise. By examining the relationship between abdominal and intermuscular fat and muscle function, the study aims to uncover the molecular mechanisms that lead to reduced exercise effectiveness. Researchers will use advanced imaging techniques and molecular analysis to assess how inflammation in fat tissue impacts muscle performance and recovery. The findings could provide insights into improving exercise outcomes for older individuals.
Why it matters
Potential benefit: If successful, this research could lead to targeted interventions that enhance exercise effectiveness and overall muscle health in older adults.
How similar studies have gone: Previous research has shown that addressing inflammation in adipose tissue can improve muscle function, suggesting potential success for this approach.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Lanza, Ian R — Mayo Clinic Rochester
- Study coordinator: Lanza, Ian R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.