How infections from Schistosomiasis mansoni and hepatitis B virus affect liver cancer in Africa
Interaction of Schistosomiasis mansoni and hepatitis B virus infections on hepatocellular carcinoma
This study is looking at how infections from Schistosomiasis and hepatitis B might work together to increase the risk of liver cancer in people living in sub-Saharan Africa, especially those with HIV, to find better ways to help those affected.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10903776 on NIH RePORTER |
What this research studies
This research investigates the relationship between Schistosomiasis mansoni and hepatitis B virus infections and their combined effect on liver cancer, specifically hepatocellular carcinoma (HCC), in sub-Saharan Africa. The study involves collaboration between institutions in Uganda, Senegal, and the United States to explore how these infections contribute to the development of HCC, particularly in HIV-positive patients. Researchers will analyze the immune responses and viral dynamics in patients undergoing treatment for Schistosomiasis to understand how it may influence hepatitis B virus replication and liver inflammation. The goal is to develop strategies to reduce the burden of HCC in affected populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living in sub-Saharan Africa who are infected with hepatitis B virus and/or Schistosomiasis mansoni, particularly those who are also HIV-positive.
Not a fit: Patients who do not have chronic infections related to hepatitis B or Schistosomiasis mansoni may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for liver cancer in patients with chronic infections.
How similar studies have performed: Previous research has identified the independent risk factors for hepatocellular carcinoma related to these infections, indicating a foundation for this investigation, though the specific interactions being studied may be novel.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Thomas, David L — Johns Hopkins University
- Study coordinator: Thomas, David L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.