How infections and warming affect the body's microbiome
Determinants of Microbiome Stability Following Pathogen Infection
['FUNDING_OTHER'] · UNIVERSITY OF HAWAII AT MANOA · NIH-11171599
This project looks at how infections and hotter temperatures change the microbes on and inside people's bodies and what helps those microbes stay or get healthy again.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF HAWAII AT MANOA (nih funded) |
| Locations | 1 site (HONOLULU, UNITED STATES) |
| Trial ID | NIH-11171599 on ClinicalTrials.gov |
What this research studies
This research studies the human microbiome — the bacteria, viruses, and fungi that live on and in our bodies — to learn what keeps it stable when disturbed by infections or long-term temperature change. Scientists will analyze microbiome composition and diversity using DNA sequencing of samples such as stool, saliva, or skin swabs, and will use lab and environmental experiments that mimic pathogen exposure and warming. The team will identify features that make some microbiomes resistant or able to recover, such as particular species or community structures. Results aim to point toward ways to protect or restore healthy microbes through treatments, lifestyle changes, or public-health strategies.
Who could benefit from this research
Good fit: Ideal participants would be people who have had recent infections or antibiotic treatment, or those exposed to higher temperatures who are willing to provide microbiome samples (for example stool, saliva, or skin swabs).
Not a fit: Patients with conditions unrelated to microbiome disturbances or those unable or unwilling to provide samples are unlikely to benefit directly from participation.
Why it matters
Potential benefit: If successful, this work could help prevent or restore harmful microbiome changes after infection or heat stress, potentially reducing complications and supporting recovery.
How similar studies have performed: Prior studies have shown infections and antibiotics can change the microbiome, but studying how long-term temperature change interacts with pathogen effects is relatively new.
Where this research is happening
HONOLULU, UNITED STATES
- UNIVERSITY OF HAWAII AT MANOA — HONOLULU, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JANI, ANDREA — UNIVERSITY OF HAWAII AT MANOA
- Study coordinator: JANI, ANDREA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Communicable Diseases