How Infection and Inflammation Affect Blood Cell Production
Impact of Infection and Inflammation on Primitive Hematopoiesis
['FUNDING_OTHER'] · BAYLOR COLLEGE OF MEDICINE · NIH-11123321
This research explores how ongoing infections and inflammation can harm the body's ability to make healthy blood cells in the bone marrow.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11123321 on ClinicalTrials.gov |
What this research studies
Our bodies rely on special cells in the bone marrow, called hematopoietic stem cells, to make billions of new blood cells every day. While inflammation helps fight off infections, long-term inflammation, like that seen in chronic infections, can actually damage these important stem cells. This damage can lead to fewer blood cells and conditions like bone marrow failure. This project aims to understand the exact ways inflammation changes these stem cells, including the genetic and molecular processes involved.
Who could benefit from this research
Good fit: This foundational research is not recruiting patients directly but aims to help those with blood diseases, bone marrow failure syndromes, or blood cancers linked to chronic inflammation.
Not a fit: Patients without conditions related to blood cell production or inflammation-induced bone marrow issues may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat blood disorders, bone marrow failure, and blood cancers caused by chronic inflammation.
How similar studies have performed: Prior work by Dr. King has already shown that prolonged inflammation can alter blood stem cells, leading to a surge of related research in this important area.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KING, KATHERINE YUDEH — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: KING, KATHERINE YUDEH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Blood Diseases, Cancers