How infection and inflammation affect blood cell production
Impact of Infection and Inflammation on Primitive Hematopoiesis
This study is looking at how inflammation affects the stem cells in your bone marrow that make blood cells, with the goal of finding ways to help people who have low blood cell counts or bone marrow problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10875576 on NIH RePORTER |
What this research studies
This research investigates how inflammation influences hematopoietic stem cells (HSCs) in the bone marrow, which are crucial for producing blood cells. It focuses on understanding the mechanisms by which inflammation can alter HSC function, leading to conditions like blood cell depletion and bone marrow failure. The study aims to identify molecular and genetic factors that regulate HSC behavior during inflammatory responses, which could provide insights into various blood diseases. By examining these processes, the research seeks to uncover potential therapeutic targets for improving blood cell production in affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with blood disorders, particularly those experiencing bone marrow failure or related complications.
Not a fit: Patients with non-hematologic conditions or those not affected by blood cell production issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for blood disorders and improve outcomes for patients with conditions like aplastic anemia and other hematologic malignancies.
How similar studies have performed: Previous research has shown promising results in understanding the role of inflammation in hematopoiesis, indicating that this approach has potential for significant advancements.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: King, Katherine Yudeh — Baylor College of Medicine
- Study coordinator: King, Katherine Yudeh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.