How infant gut bacteria and breastmilk affect brain development in children exposed to HIV
Influence of infant gut microbiome and breastmilk HMOs on neurodevelopment in children exposed to HIV
This study is looking at how the bacteria in the gut and the nutrients in breastmilk might affect the brain development of children who are exposed to HIV but are not infected, compared to those who aren't exposed, to find ways to support their growth and learning.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10381036 on NIH RePORTER |
What this research studies
This research investigates the impact of the gut microbiome and breastmilk composition on the neurodevelopment of children who are exposed to HIV but are uninfected. By comparing a group of these children with those who are unexposed to HIV, the study aims to identify factors that may contribute to neurodevelopmental challenges. The research will focus on understanding how the gut microbiome, influenced by maternal health and feeding practices, can affect brain development in early childhood. This longitudinal study will collect data over several years to track developmental outcomes and potential modifiable factors.
Who could benefit from this research
Good fit: Ideal candidates for participation include infants and young children under 11 years old who are exposed to HIV but uninfected.
Not a fit: Children who are HIV positive or those who are not exposed to HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing brain development in children exposed to HIV.
How similar studies have performed: Previous studies have shown promising results in understanding the role of the gut microbiome in child development, suggesting that this approach could yield valuable insights.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Benki-Nugent, Sarah F. — University of Washington
- Study coordinator: Benki-Nugent, Sarah F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.