NIH-funded research NIH-funded research

How individual differences in behavior are shaped by reward associations

Official title: Individual differences through self-reinforcement of suboptimal strategies

Funded at Princeton University · NIH-10911260 · Data updated 2026-11-12

This study is looking at how our unique experiences with rewards can shape our behavior differently, and it’s for anyone curious about why people react in various ways to similar situations, using brain activity related to learning from rewards.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionPrinceton University
NIH-funded
Lab location1 site (Princeton, UNITED STATES)
Project startAugust 21, 2023
Project endJuly 31, 2028
Funding year2024
Award (this year)$1,148,000
NIH project number5DP1MH136573-02
Project IDNIH-10911260 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are individuals who exhibit notable differences in behavior and learning patterns.

Less likely to help

Patients with uniform behavioral responses or those not exhibiting variability in learning may not benefit from this research.

What this research studies

This research investigates how individual differences in behavior arise from the unique reward associations that people form in similar environments. By studying dopamine neurons, which play a crucial role in how we learn from rewards, the research aims to understand how small variations in initial conditions can lead to significant differences in behavior. The approach involves recording dopamine neuron activity to analyze how different individuals predict rewards based on their experiences. This could provide insights into the mechanisms behind behavioral variability and learning processes.

Why it matters

Potential benefit: If successful, this research could enhance our understanding of behavioral differences, potentially leading to improved strategies for behavioral interventions and treatments.

How similar studies have gone: Other research has shown success in understanding behavioral variability through similar approaches, particularly in the context of dopamine's role in reward processing.

Where this research is happening

  • Princeton University
    Princeton, United States
    Active

Researchers

  • Principal investigator: Witten, Ilana — Princeton University
  • Study coordinator: Witten, Ilana

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.