How individual cells differ and change over time
Defining a biophysical basis for cell types, cell states and cellular heterogeneity at single-cell resolution
['FUNDING_OTHER'] · JOHNS HOPKINS UNIVERSITY · NIH-11249549
This project develops new ways to read a single cell's internal signals and behaviors to better understand aging cells and T-cells that matter for immune and age-related diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11249549 on ClinicalTrials.gov |
What this research studies
This work develops integrated single-cell technologies that link molecular programs to cell behaviors and responses. The team will apply these tools to study how epigenomic programs drive cell senescence, how transcriptional programs shape T-cell behavior for engineered immune cells, and how T-cells change during differentiation. Experiments will combine molecular profiling with biophysical measurements at single-cell resolution using laboratory model systems and disease-relevant cells. The goal is to map how cellular identities form and change in health and disease to inform future therapies.
Who could benefit from this research
Good fit: People with immune-related conditions, cancer patients receiving or eligible for cell therapies, older adults with age-related disorders, or anyone able to donate blood or tissue samples for research would be most relevant.
Not a fit: Patients whose conditions are unrelated to immune function or cellular aging, or those unable or unwilling to provide samples, are unlikely to benefit directly from this basic-science project.
Why it matters
Potential benefit: If successful, this could reveal new cellular targets and improve design of cell-based therapies for immune and age-related diseases.
How similar studies have performed: Single-cell molecular profiling has already uncovered disease-linked cell states, but combining those approaches with detailed biophysical measurements is relatively new and less tested.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PHILLIP, JUDE MARVIN — JOHNS HOPKINS UNIVERSITY
- Study coordinator: PHILLIP, JUDE MARVIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.