How incarceration history affects midlife health and dementia risk

Consequences of Incarceration on Health, Age-Related Conditions, and Risk Factors for ADRD

NIH-funded research Northwestern University · NIH-11308740

Researchers will follow adults who were incarcerated as youth to learn how jail and prison experiences relate to health in midlife and future dementia risk.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionNorthwestern University NIH-funded
Lab location1 site (Chicago, United States)
Project IDNIH-11308740 on NIH RePORTER

What this research studies

This project follows people from a long-term group who were involved with the juvenile justice system and are now in their 40s. If you join, researchers will collect your health measurements, surveys, and detailed incarceration history to examine how frequency, duration, age at incarceration, and facility type relate to midlife health and dementia risk. The team will focus on changeable risk factors like high blood pressure, diabetes, smoking, alcohol use, obesity, exercise, depression, and social connections. Methods include interviews, medical exams, and review of records to identify factors that could be changed to lower future dementia risk.

Who could benefit from this research

Good fit: Ideal participants are adults now in midlife (around 39–49) who experienced incarceration as adolescents or young adults and are willing to share health information and records.

Not a fit: People without a history of incarceration or those well outside the midlife age range are unlikely to gain direct benefit from participating.

Why it matters

Potential benefit: If successful, the project could identify specific changeable health factors linked to incarceration and inform programs to reduce dementia risk among formerly incarcerated people.

How similar studies have performed: Few prior studies have looked prospectively at incarceration 'dose' and dementia risk, though a small pilot (n=65) showed the methods are feasible.

Where this research is happening

Chicago, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.