How immune “training” and cell energy affect children and teens born with HIV
The role of Trained Immunity and Mitochondrial dysfunction on INnate immunity in children and adolescents aGing with PHIV (TIMING-PHIV)
['FUNDING_U01'] · OHIO STATE UNIVERSITY · NIH-11310138
This project looks at how long-term HIV infection and antiretroviral treatment change immune cell behavior and mitochondrial health in children and adolescents born with HIV.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-11310138 on ClinicalTrials.gov |
What this research studies
If you join, researchers will collect blood samples and medical history from children and teens born with HIV to measure immune cell activation, markers of 'trained immunity,' and mitochondrial function. They will compare these measures with HIV-negative peers and relate findings to antiretroviral drug exposure, adherence history, and clinical health. Laboratory tests will focus on monocytes, macrophages, and natural killer cells and use mitochondrial assays to link immune changes to signs of early aging. The work is carried out in an adolescent cohort in Uganda with collaboration from U.S. investigators.
Who could benefit from this research
Good fit: Children and adolescents who were infected with HIV at birth (perinatally acquired HIV) and who are on or have a history of long-term antiretroviral therapy are the ideal candidates.
Not a fit: People who acquired HIV later in life, who are HIV-negative, or who are not on ART are unlikely to benefit directly from this specific project.
Why it matters
Potential benefit: If successful, this work could point to ways to reduce chronic inflammation and prevent early aging-related health problems in people born with HIV.
How similar studies have performed: Previous studies, including the investigators' own work, have found immune differences in perinatally infected youth, but combining trained immunity and mitochondrial function measurements is a newer approach.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FUNDERBURG, NICHOLAS T. — OHIO STATE UNIVERSITY
- Study coordinator: FUNDERBURG, NICHOLAS T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus