How immune signaling affects bone changes and inflammation in osteoarthritis.
Official title: The impact of TLR signaling on osteoclast-mediated bone remodeling and inflammation in osteoarthritis.
Funded at University of Pennsylvania · NIH-10996052 · Data updated 2026-11-12
This study is looking at how a part of the immune system affects inflammation and bone changes in people with osteoarthritis, with the goal of finding new ways to help manage the condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31AR084868-01 |
| Project ID | NIH-10996052 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with osteoarthritis, particularly those experiencing significant joint pain and inflammation.
✕Less likely to help
Patients with osteoarthritis who do not exhibit inflammation or those with other unrelated joint conditions may not benefit from this research.
What this research studies
This research investigates the role of Toll-like receptor (TLR) signaling in the inflammation and bone remodeling associated with osteoarthritis (OA). It focuses on understanding how chronic low-level inflammation contributes to the progression of OA, particularly in the subchondral bone. By studying immune cells and their interactions in joint tissues, the research aims to uncover mechanisms that could lead to new treatment strategies for OA. The approach includes using animal models to observe the effects of TLR signaling on bone health and inflammation.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that alleviate pain and improve joint function for patients with osteoarthritis.
How similar studies have gone: Previous studies have shown that targeting inflammatory pathways in osteoarthritis can lead to meaningful improvements, suggesting that this approach may also yield beneficial results.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Murphy, Lance Avery — University of Pennsylvania
- Study coordinator: Murphy, Lance Avery
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.