How immune responses affect the creation of antibodies from HIV vaccines
Official title: Project 1: The impact of innate immune responses on the development of broadly neutralizing antibodies by vaccination
Funded at Univ of North Carolina Chapel Hill · NIH-11059130 · Data updated 2026-11-12
This study is looking at ways to make HIV vaccines work better by boosting the body's immune response to create special antibodies that can fight different strains of the virus, and it's designed for anyone interested in improving HIV prevention.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | June 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $252,827 |
| NIH project number | 5P01AI178377-03 |
| Project ID | NIH-11059130 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults who are at risk for HIV or those interested in participating in HIV vaccine trials.
✕Less likely to help
Patients who are not at risk for HIV or those who have already been vaccinated against HIV may not benefit from this research.
What this research studies
This research investigates how the body's immune responses can be harnessed to improve the effectiveness of HIV vaccines. It focuses on the development of broadly neutralizing antibodies (bNAbs) that can target various strains of the virus. By using specific adjuvants, which are substances that enhance the body's immune response to vaccines, the study aims to identify mechanisms that can boost the production and maturation of these important antibodies. The research involves both animal models and innovative vaccine designs to explore these interactions.
Why it matters
Potential benefit: If successful, this research could lead to more effective HIV vaccines that provide broader protection against the virus.
How similar studies have gone: Previous studies have shown promise in enhancing antibody responses through the use of adjuvants, indicating that this approach has potential for success.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: De Paris, Kristina — Univ of North Carolina Chapel Hill
- Study coordinator: De Paris, Kristina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.