How immune responses affect heart failure and recovery
Official title: Coordination of cardiac inflammation/remodeling in heart failure by myeloid catabolism of purinergic DAMPs
Funded at Veterans Health Administration · NIH-10975913 · Data updated 2026-11-12
This study is looking at how the immune system affects heart failure by exploring how immune cells and heart cells work together when the heart is under stress, with the goal of finding new ways to improve treatments for people with heart failure.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | October 1, 2023 |
| Project end | September 30, 2027 |
| Funding year | 2025 |
| NIH project number | 5I01CX002560-02 |
| Project ID | NIH-10975913 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with heart failure, particularly those experiencing acute heart failure.
✕Less likely to help
Patients with heart failure who do not have significant immune system involvement or those with other unrelated conditions may not benefit from this research.
What this research studies
This research investigates the role of immune responses in heart failure, particularly focusing on how certain immune cells interact with heart cells under stress. It examines the release of purines, like ATP, from heart cells and how these substances influence inflammation and remodeling in the heart. By studying genetic variants and inflammatory markers in patients, the research aims to uncover mechanisms that could lead to better treatments for heart failure. The approach includes both laboratory experiments and analysis of patient data to understand the connections between immune function and heart health.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart function and reduce hospitalizations for patients with heart failure.
How similar studies have gone: Other research has shown promising results in understanding immune responses in heart conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Veterans Health Administration
Ann Arbor, United States Active
Researchers
- Principal investigator: Goonewardena, Sascha Nilu — Veterans Health Administration
- Study coordinator: Goonewardena, Sascha Nilu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.