How immune responses affect gut health and cancer development
Ubiquitination, Intestinal Homeostasis and Cancer
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10908477
This study is looking at how our immune system and gut health are connected, especially how inflammation might lead to colon cancer, using a special mouse model to find out what goes wrong and how we might develop better treatments or prevention for bowel cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10908477 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between immune responses and intestinal health, particularly how inflammation can lead to colon cancer. By studying a special mouse model that mimics human conditions, researchers aim to identify the immune factors that disrupt normal intestinal function and promote cancer. The study employs advanced techniques like transcriptomics and proteomics to analyze cellular interactions and signaling pathways involved in these processes. Patients may benefit from insights that could lead to new treatments or preventive strategies for bowel cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 who are at risk for or have a history of bowel cancer.
Not a fit: Patients with non-intestinal cancers or those without any gastrointestinal issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve gut health and reduce the risk of colon cancer.
How similar studies have performed: Previous research has shown success in understanding the role of immune responses in cancer development, making this approach promising.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MA, AVERIL I — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: MA, AVERIL I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bowel Cancer