How immune profiles affect colorectal cancer outcomes across different racial groups
Variation in tumor-associated immune profiles and colorectal cancer outcomes
This study is looking at how different racial and ethnic groups respond to colorectal cancer treatments, especially immunotherapy, by examining their immune systems to help improve outcomes for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10909148 on NIH RePORTER |
What this research studies
This research investigates the differences in immune responses to colorectal cancer (CRC) among various racial and ethnic populations. It aims to understand how these variations in immune profiles may influence treatment responses, particularly to immunotherapy. By analyzing tumor-infiltrating lymphocytes (TIL) and considering genetic ancestry, the study seeks to uncover factors that contribute to disparities in cancer outcomes. The research will utilize advanced methodologies to assess immune responses beyond self-reported racial categories, providing a more accurate understanding of the influences at play.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with colorectal cancer, particularly those from diverse racial and ethnic backgrounds.
Not a fit: Patients with colorectal cancer who do not belong to the studied racial or ethnic groups may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment strategies for colorectal cancer based on a patient's genetic and immune profile.
How similar studies have performed: Previous studies have shown that understanding genetic and immune diversity can lead to significant advancements in cancer treatment, suggesting a promising avenue for this research.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Schmit, Stephanie L. — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Schmit, Stephanie L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.