How immune genes affect Alzheimer's disease related to herpes virus
Official title: Immunoglobulin Genes and Immunity to HSV1 in Alzheimer's Disease
Funded at Medical University of South Carolina · NIH-11078859 · Data updated 2026-11-12
This study is looking at how certain genes related to the immune system might affect the risk and severity of Alzheimer's disease in people who have been infected with the herpes simplex virus, and it invites patients to share their genetic samples and health information to help us understand this connection better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project start | August 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $369,950 |
| NIH project number | 5R01AG080451-03 |
| Project ID | NIH-11078859 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease who have a history of herpes simplex virus type 1 infection.
✕Less likely to help
Patients without Alzheimer's disease or those who have not been infected with HSV1 may not benefit from this research.
What this research studies
This research investigates the relationship between immune system genes and the development of Alzheimer's disease (AD) in individuals infected with the herpes simplex virus type 1 (HSV1). It aims to understand how genetic factors may influence the severity of AD in those with HSV1, focusing on specific immunoglobulin genes that could modify this association. By analyzing genetic data and immune responses, the study seeks to uncover potential pathways that link HSV1 infection to Alzheimer's disease progression. Patients may be involved in providing genetic samples and health information to help clarify these connections.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic factors that influence Alzheimer's disease, potentially guiding future treatments or preventive strategies.
How similar studies have gone: While the connection between viral infections and Alzheimer's disease is being explored, this specific focus on immunoglobulin genes and HSV1 is relatively novel and has not been extensively tested in prior research.
Where this research is happening
-
Medical University of South Carolina
Charleston, United States Active
Researchers
- Principal investigator: Pandey, Janardan P — Medical University of South Carolina
- Study coordinator: Pandey, Janardan P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.