How immune function, metabolism, and gut bacteria affect urinary tract infections caused by Group B Streptococcus.
Contribution of immune modulation, metabolism, and microbiota to Group B Streptococcal urinary tract infection
This study is looking at how the immune system, metabolism, and gut bacteria work together in people with urinary tract infections caused by Group B Streptococcus, especially those with type 2 diabetes, to understand why they might get these infections more often and find better ways to help them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10874763 on NIH RePORTER |
What this research studies
This research investigates the relationship between immune system function, metabolic health, and the presence of gut bacteria in patients with urinary tract infections (UTIs) caused by Group B Streptococcus (GBS). It focuses on understanding why individuals with type 2 diabetes are more susceptible to these infections and how their unique biological pathways may contribute to this increased risk. By studying diabetic mice, the researchers aim to uncover the molecular mechanisms that lead to heightened vulnerability to GBS infections, which could inform future treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with type 2 diabetes who experience recurrent urinary tract infections.
Not a fit: Patients without diabetes or those who do not experience urinary tract infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for urinary tract infections in patients with diabetes.
How similar studies have performed: Previous research has shown that understanding the interactions between diabetes and urinary tract infections can lead to significant advancements in treatment, suggesting that this approach has potential for success.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Patras, Katy — Baylor College of Medicine
- Study coordinator: Patras, Katy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.