How immune cells respond to inflammation and cancer
Official title: Regulation of hematopoiesis and trained immunity by innate lymphocytes
Funded at Yale University · NIH-10992175 · Data updated 2026-11-12
This study looks at how certain blood cells in your body learn to respond better to infections and cancer after facing inflammation, helping us understand how to boost your immune system for future challenges.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | December 1, 2023 |
| Project end | October 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $203,094 |
| NIH project number | 5R21AI180408-02 |
| Project ID | NIH-10992175 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of severe infections or cancer who are interested in understanding their immune response.
✕Less likely to help
Patients who do not have any history of inflammatory conditions or cancer may not receive direct benefits from this research.
What this research studies
This research investigates how hematopoietic stem and progenitor cells (HSPCs) react to inflammation caused by severe infections and cancer. It focuses on a process called 'trained immunity,' where these cells adapt and enhance their response to future inflammatory challenges. By analyzing immune cells from bone marrow, the study aims to uncover the cellular mechanisms and molecular pathways that regulate this adaptive immune response. Patients may benefit from a better understanding of how their immune system can be trained to respond more effectively to infections and tumors.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance the immune system's ability to fight infections and cancer.
How similar studies have gone: Other research has shown promising results in understanding immune responses, but this specific approach to trained immunity is relatively novel.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Flavell, Richard a — Yale University
- Study coordinator: Flavell, Richard a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.