How immune cells remember and respond to different infections
NFkB dynamics in the stimulus specificity of trained immunity
['FUNDING_CAREER'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11017743
This study is looking at how certain immune cells in your body can learn to react differently to infections based on their past experiences, and it aims to find ways to help these cells respond better when you get sick.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11017743 on ClinicalTrials.gov |
What this research studies
This research investigates how certain immune cells, like monocytes and macrophages, can be 'trained' by their environment to respond differently to infections. By examining the role of a protein called NFκB, the research aims to understand how these cells change their behavior based on previous encounters with pathogens. The study focuses on the epigenetic changes that occur in these cells, which can either enhance or reduce their inflammatory responses during subsequent infections. This knowledge could lead to new strategies for improving immune responses in patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that affect their immune response, such as recurrent infections or inflammatory diseases.
Not a fit: Patients with stable immune conditions or those not experiencing immune-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for infections by enhancing the body's immune response.
How similar studies have performed: Other research has shown promising results in understanding immune cell behavior, making this approach both relevant and potentially impactful.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHENG, QUEN J — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: CHENG, QUEN J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.