How immune cells regulate gene expression over time
Official title: Temporal Regulation of mRNA Biogenesis in Immune Responses
Funded at Univ of Massachusetts Med Sch Worcester · NIH-11070456 · Data updated 2026-11-12
This study is looking at how immune cells, like macrophages, produce important messages that help them remember past infections and respond better to new ones, which could help improve our understanding of how to boost our immune system.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | February 10, 2025 |
| Project end | February 9, 2027 |
| Funding year | 2025 |
| Award (this year) | $33,806 |
| NIH project number | 1F31AI189160-01 |
| Project ID | NIH-11070456 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that affect immune responses, such as recurrent infections or autoimmune disorders.
✕Less likely to help
Patients with stable, non-immune related conditions may not receive direct benefits from this research.
What this research studies
This research investigates the timing and regulation of mRNA production in immune cells, particularly focusing on how these processes affect the body's response to infections. By examining the intricate steps involved in gene expression during immune responses, the study aims to understand how immune cells, like macrophages, can remember past infections and respond more effectively to future threats. The research employs advanced techniques to analyze the dynamics of mRNA biogenesis and its implications for immune memory and response efficiency.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing immune responses in patients, potentially leading to better vaccines or therapies for infections.
How similar studies have gone: Previous research has shown promising results in understanding immune memory and gene regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Univ of Massachusetts Med Sch Worcester
Worcester, United States Active
Researchers
- Principal investigator: Lehman, Jesse William — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Lehman, Jesse William
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.