How immune cells move and respond to signals in the body
Mechanisms of Signaling on Membrane Surfaces
This study is looking at how certain immune cells called macrophages move to areas in the body that are infected or damaged, and it aims to find ways to improve this process, which could help in treating conditions like cancer and autoimmune diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project ID | NIH-11001558 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which immune cells, specifically macrophages, navigate towards sites of infection or tissue damage. It focuses on the role of specific lipid kinases that regulate cell movement and the engulfing of pathogens. By understanding these signaling pathways, the research aims to uncover how these processes can be influenced, potentially leading to new treatments for diseases like cancer and autoimmune disorders. The study employs advanced techniques to analyze cell behavior and signaling at the molecular level.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with autoimmune diseases, cancer, or those experiencing chronic inflammation.
Not a fit: Patients with stable, non-inflammatory conditions or those not affected by immune system dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance immune responses against infections and cancers.
How similar studies have performed: Previous research has shown that targeting similar signaling pathways can lead to significant advancements in treating immune-related diseases.
Where this research is happening
Boulder, UNITED STATES
- University of Colorado — Boulder, United States (Active)
Researchers
- Principal investigator: Falke, Joseph J — University of Colorado
- Study coordinator: Falke, Joseph J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.