How immune cells interact with surrounding tissue to maintain health and respond to inflammation
Understanding Immune-Stromal Interactions in Tissue Homeostasis and Inflammation
This study is looking at how immune cells talk to and work with the surrounding tissue to keep it healthy, and it aims to find new ways to help treat inflammatory diseases and tissue problems that you might be dealing with.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11124865 on NIH RePORTER |
What this research studies
This research investigates the interactions between immune cells and the surrounding tissue stroma, focusing on how these interactions influence tissue health and inflammation. The team aims to understand the mechanisms by which immune cells, particularly macrophages and fibroblasts, communicate and organize within tissues. By studying these cellular interactions, the research seeks to uncover ways to program immune responses to restore tissue balance in disease conditions. Patients may benefit from insights that could lead to new treatments for inflammatory diseases and tissue disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with inflammatory diseases or conditions affecting tissue homeostasis.
Not a fit: Patients with acute infections or those not experiencing tissue-related disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that enhance the body's ability to restore tissue health and manage inflammation.
How similar studies have performed: Previous research has shown promising results in understanding immune cell interactions, suggesting that this approach could yield significant insights.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Zhou, Xu — Boston Children's Hospital
- Study coordinator: Zhou, Xu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.