How immune cells interact with gut bacteria to influence cancer outcomes
Innate lymphoid cell regulation of the host-microbiota interactions in cancer
This study is looking at how your immune system and gut bacteria work together and how that affects colorectal cancer and its treatment, especially focusing on a special immune cell type, to find new ways to make cancer therapies more effective.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10977469 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between the immune system and gut microbiota, particularly focusing on how these interactions affect cancer progression and treatment responses. The study aims to understand the role of a specific type of immune cell, known as innate lymphoid cells (ILC3s), in regulating these interactions and their implications for colorectal cancer. By exploring the mechanisms that govern these relationships, the research seeks to identify potential therapeutic targets that could enhance the effectiveness of immunotherapies in cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with colorectal cancer who may benefit from novel immunotherapy approaches.
Not a fit: Patients with cancers other than colorectal cancer or those not undergoing immunotherapy may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer treatments by harnessing the power of the microbiota to enhance immune responses against tumors.
How similar studies have performed: Other studies have shown promising results in understanding the role of microbiota in cancer, suggesting that this approach could yield significant insights and advancements.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Sonnenberg, Gregory F — Weill Medical Coll of Cornell Univ
- Study coordinator: Sonnenberg, Gregory F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.