How immune cells interact with gut bacteria to influence cancer outcomes
Innate lymphoid cell regulation of the host-microbiota interactions in cancer
['FUNDING_R01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-10898057
This study is looking at how your immune system and gut bacteria work together and how this affects colorectal cancer and its treatment, especially focusing on a type of immune cell that might help fight tumors and improve immunotherapy for patients like you.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10898057 on ClinicalTrials.gov |
What this research studies
This research investigates the complex interactions between the immune system and gut microbiota, particularly focusing on how these interactions can influence cancer progression and treatment responses. The study aims to understand the role of a specific type of immune cell, known as innate lymphoid cells (ILC3s), in colorectal cancer and how they may protect against tumor growth while also affecting the effectiveness of immunotherapy. By exploring these mechanisms, the research seeks to identify potential therapeutic targets that could enhance cancer treatment outcomes for patients. Patients may benefit from insights that could lead to improved immunotherapy strategies tailored to their unique microbiota profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with colorectal cancer who are undergoing or considering immunotherapy.
Not a fit: Patients with cancers other than colorectal cancer or those not receiving immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing cancer treatment and improving patient outcomes through better understanding of gut microbiota interactions.
How similar studies have performed: Other research has shown promising results in understanding the role of microbiota in cancer treatment, suggesting that this approach could lead to significant advancements.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SONNENBERG, GREGORY F — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: SONNENBERG, GREGORY F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Model, CancerModel, Cancers