How immune cells interact during infections caused by a common fungus.
Official title: Lymph node stromal cells coordinate immune cell environments during Aspergillus fumigatus infection
Funded at Weill Medical Coll of Cornell Univ · NIH-10880264 · Data updated 2026-11-12
This study is looking at how certain cells in your lymph nodes help your immune system fight off a fungus called Aspergillus fumigatus, which can be a big problem for people with weakened immune systems, and it hopes to find new ways to boost your immune response against this infection.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $53,894 |
| NIH project number | 5F30AI179148-02 |
| Project ID | NIH-10880264 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are immunocompromised individuals or those with conditions that increase their risk of Aspergillus infections.
✕Less likely to help
Patients who are not immunocompromised or do not have a history of Aspergillus infections may not benefit from this research.
What this research studies
This research investigates how lymph node stromal cells influence the immune response to Aspergillus fumigatus, a fungus that can cause serious infections, especially in immunocompromised patients. By examining the spatial organization of immune cells in lymph nodes during infection, the study aims to understand how different types of T cells are activated and function. The researchers will use advanced techniques like single-cell RNA sequencing to analyze immune cell interactions and identify potential therapeutic targets for improving immune responses.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the immune response against Aspergillus fumigatus infections, potentially reducing mortality rates in vulnerable patients.
How similar studies have gone: Previous research has shown success in understanding immune responses to fungal infections, but this specific approach to studying lymph node microenvironments is relatively novel.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Mai, Cheryl — Weill Medical Coll of Cornell Univ
- Study coordinator: Mai, Cheryl
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.