How immune cells influence prostate development and growth
Regulation of prostate organogenesis by tissue-resident macrophages
This study is looking at how certain immune cells called macrophages affect the growth of the prostate and may play a role in non-cancerous prostate issues, helping us better understand conditions like benign prostate hyperplasia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | George Washington University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-10978205 on NIH RePORTER |
What this research studies
This research investigates the role of immune cells, specifically macrophages, in the development of the prostate gland and how they may contribute to benign prostate conditions. By examining the interactions between these immune cells and prostate tissue during critical growth periods, the study aims to uncover the mechanisms that regulate prostate organogenesis. The research utilizes advanced techniques such as single-cell RNA sequencing to analyze the diversity of cell types in the prostate and their responses to androgens. Ultimately, the goal is to enhance our understanding of benign prostate hyperplasia and its progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are adult males experiencing symptoms related to benign prostate hyperplasia.
Not a fit: Patients with prostate cancer or other severe prostate conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapeutic strategies for managing benign prostate hyperplasia.
How similar studies have performed: While the role of immune cells in other organ systems has been studied, this specific focus on macrophages in prostate organogenesis is relatively novel and untested.
Where this research is happening
Washington, United States
- George Washington University — Washington, United States (Active)
Researchers
- Principal investigator: Shibata, Maho — George Washington University
- Study coordinator: Shibata, Maho
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.