How immune cells in the brain affect its development and recovery from injury
Meningeal type 2 immunity in cortical synapse remodeling during brain development and injury
This study is looking at special immune cells in the brain to see how they help the brain grow and heal after injuries, which could lead to better treatments for conditions like autism and brain injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11002717 on NIH RePORTER |
What this research studies
This research investigates the role of immune cells in the brain, particularly focusing on how they influence brain development and recovery after injuries. It examines a specific type of immune cell, known as group 2 innate lymphoid cells (ILC2s), which are found in the brain's protective layers and are activated during critical periods of brain development. By studying these cells and their interactions with brain structures, the research aims to uncover mechanisms that could lead to better understanding and treatment of neurodevelopmental disorders like autism and the effects of brain injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals under 21 years old with autism spectrum disorders or those who have experienced acquired brain injuries.
Not a fit: Patients with neurodevelopmental disorders unrelated to immune dysregulation or those over 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neurodevelopmental disorders and improved recovery methods for brain injuries.
How similar studies have performed: Other research has shown promising results in understanding the role of immune cells in brain function, suggesting that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Molofsky, Ari B — University of California, San Francisco
- Study coordinator: Molofsky, Ari B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.