How immune cells in the body and brain interact in Alzheimer's
The adaptive-innate immune interactome across multiple tissues in Alzheimer's disease
This project looks at how different immune cells in the blood, cerebrospinal fluid, and brain behave together in people with Alzheimer's disease to find clues that could slow brain damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11262896 on NIH RePORTER |
What this research studies
Researchers will collect blood, cerebrospinal fluid, and fresh brain tissue when available from people with Alzheimer's and comparison subjects and isolate immune cells for detailed single-cell analysis. They will compare adaptive (T and B cell) and innate (microglia, astrocytes) immune activity across multiple tissues and stages of disease. The team will combine human sample data with mouse experiments that test key immune signals to understand cause-and-effect. The goal is to map immune interactions that might protect or harm the brain in Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates are people diagnosed with Alzheimer's disease or related dementia who can provide blood or cerebrospinal fluid samples, and individuals or families willing to donate brain tissue for research.
Not a fit: This is not a treatment trial, so people seeking an experimental therapy or those unable to provide samples or visit study sites are unlikely to benefit directly from participation.
Why it matters
Potential benefit: If successful, the work could point to immune-related biomarkers or new targets for treatments that slow or prevent Alzheimer's-related brain damage.
How similar studies have performed: Prior studies have found expanded T cells and immune signaling effects in human and mouse Alzheimer's samples, so the approach builds on emerging but still early evidence.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Roussos, Panagiotis — Icahn School of Medicine at Mount Sinai
- Study coordinator: Roussos, Panagiotis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.