How immune cells help skin heal after nerve injuries
Official title: Role of immune cells in skin reinnervation by collateral sprouting after peripheral nerve injury
Funded at Johns Hopkins University · NIH-11061823 · Data updated 2026-11-12
This study is looking at how certain immune cells in your skin help it heal and grow back after nerve injuries, and it’s for anyone interested in understanding how our bodies repair themselves.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $424,905 |
| NIH project number | 5R01NS132879-02 |
| Project ID | NIH-11061823 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced peripheral nerve injuries and are dealing with sensory dysfunction or neuropathic pain.
✕Less likely to help
Patients with nerve injuries that are not peripheral or those who do not experience sensory loss may not benefit from this research.
What this research studies
This research investigates the role of immune cells, specifically macrophages, in the healing process of skin following peripheral nerve injuries. It aims to understand how these immune cells contribute to the reinnervation of skin by promoting the growth of nerve fibers from uninjured neurons. The study will involve examining the behavior and characteristics of macrophages in the skin over time after nerve injury, as well as their relationship with nerve fibers that are sprouting. By using advanced techniques, the research seeks to uncover the mechanisms behind this healing process.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from sensory loss and chronic pain due to nerve injuries.
How similar studies have gone: Previous research has shown promising results in understanding nerve regeneration mechanisms, but the specific role of macrophages in collateral sprouting is still being explored.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Jeon, Sangmin — Johns Hopkins University
- Study coordinator: Jeon, Sangmin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.