How immune cells help heal and regulate inflammation in tissues
Macrophage-mediated regulation of inflammation and tissue repair
['FUNDING_OTHER'] · HARVARD MEDICAL SCHOOL · NIH-11077991
This study is looking at how special immune cells called macrophages help reduce inflammation and heal damaged tissues, especially in areas like the gut that can get hurt by viruses or chemicals, which could lead to better treatments for people dealing with these issues.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD MEDICAL SCHOOL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11077991 on ClinicalTrials.gov |
What this research studies
This research investigates the role of macrophages, a type of immune cell, in managing inflammation and aiding tissue repair, particularly in mucosal tissues that are often exposed to damage. The study will explore how these cells interact with epithelial cells after injuries caused by viruses or chemicals. Using both live animal models and lab-grown organoid systems, the research aims to uncover the mechanisms by which macrophages influence inflammation and promote healing. This could lead to new insights into how to enhance tissue repair processes in patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve mucosal tissue damage or chronic inflammation.
Not a fit: Patients with stable, non-inflammatory conditions or those not involving mucosal tissues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions involving tissue damage and inflammation.
How similar studies have performed: Previous research has shown promising results in understanding the role of immune cells in tissue repair, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- HARVARD MEDICAL SCHOOL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FRANKLIN, RUTH A — HARVARD MEDICAL SCHOOL
- Study coordinator: FRANKLIN, RUTH A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.