How immune cells are controlled by tiny channels
Immune cell regulation by swelling-activated ion channels
This project explores how tiny channels on immune cells, called T lymphocytes, help them work properly.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11176321 on NIH RePORTER |
What this research studies
Our bodies' immune cells, especially T lymphocytes, rely on special proteins called ion channels to function correctly. This project aims to discover how these channels, particularly those activated by cell swelling, provide crucial signals for T cells to mature and develop. We also want to understand how these channels transport important signaling molecules within immune cells. By using advanced methods like genetic mouse models and detailed cell studies, we hope to uncover the complex ways ion channels regulate immune cell activity.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage.
Not a fit: Patients seeking immediate new treatments will not directly benefit from this early-stage basic science.
Why it matters
Potential benefit: Understanding these fundamental mechanisms could lead to new strategies for treating diseases where immune cells are not functioning as they should.
How similar studies have performed: While the specific role of swelling-activated ion channels in immune cells is less understood, prior genetic evidence has shown that ion channels are critically important for immune cell function.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Concepcion Gonzalez, Axel Rolando — University of Chicago
- Study coordinator: Concepcion Gonzalez, Axel Rolando
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.