How immune cells affect the function of the gut's nervous system
Official title: Regulation of Enteric Nervous System Function by Group 3 Innate Lymphoid Cells
Funded at Weill Medical Coll of Cornell Univ · NIH-11058406 · Data updated 2026-11-12
This study is looking at how certain immune cells in your gut interact with the nervous system there, especially when things get inflamed, to find new ways to keep your gut healthy and possibly create better treatments for gut issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $80,224 |
| NIH project number | 5F32DK136248-03 |
| Project ID | NIH-11058406 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with gastrointestinal disorders, particularly those experiencing inflammation or related conditions.
✕Less likely to help
Patients with non-gastrointestinal conditions or those not experiencing any intestinal issues may not benefit from this research.
What this research studies
This research investigates the interactions between the enteric nervous system (ENS) and innate lymphoid cells (ILCs), which are immune cells that play a role in gut health. The study aims to understand how ILCs influence the ENS, particularly during inflammation, by using both live animal models and laboratory techniques. By exploring the molecular and cellular mechanisms involved, the research seeks to uncover new ways to maintain gut health and potentially develop new treatments for intestinal diseases.
Why it matters
Potential benefit: If successful, this research could lead to innovative strategies for preventing or treating intestinal disorders, improving overall gut health.
How similar studies have gone: While the role of ILCs in the ENS is a relatively novel area of investigation, similar studies have shown promising results in understanding immune interactions in other tissues.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Zhou, Jordan Zheng — Weill Medical Coll of Cornell Univ
- Study coordinator: Zhou, Jordan Zheng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.