How Immune Cells Affect Heart Disease
Neutrophil Development During Inflammation and Atherosclerosis
This project explores how certain immune cells called neutrophils develop and contribute to heart disease, aiming to find new ways to help patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11187030 on NIH RePORTER |
What this research studies
Neutrophils are immune cells that respond to inflammation and play a role in heart disease. This project explores how these cells are produced in the bone marrow and how they change when inflammation is present, especially in people with cardiovascular disease. Researchers are particularly interested in a specific type of early neutrophil cell found in both mice and humans with heart disease. By understanding how these cells become active and contribute to inflammation, we hope to uncover new ways to slow down or prevent the progression of heart disease.
Who could benefit from this research
Good fit: Patients with atherosclerotic cardiovascular disease, particularly those experiencing inflammation, could potentially benefit from future therapies developed from this research.
Not a fit: Patients without atherosclerotic cardiovascular disease or related inflammatory conditions would likely not receive direct benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that target specific immune cells to reduce inflammation and slow the progression of atherosclerotic cardiovascular disease.
How similar studies have performed: This research builds upon recent discoveries about early neutrophil progenitor stem cells in humans and mice with CAD, suggesting a novel approach to understanding disease progression.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Hedrick, Catherine C — Scripps Research Institute, the
- Study coordinator: Hedrick, Catherine C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.