How immune cells affect heart changes during stress
Immune Mechanisms Regulating Cardiac Remodeling
This study is looking at how certain immune cells in your body can help your heart respond better to stress from things like exercise or illness, with the goal of finding new ways to prevent heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10766168 on NIH RePORTER |
What this research studies
This research investigates how immune cells, specifically macrophages and B cells, influence the heart's response to stress, such as exercise or disease. By examining the early phases of cardiac remodeling, the study aims to understand how these immune cells can promote beneficial changes or prevent harmful ones. The researchers will use innovative technologies to explore the activation of these immune cells and their interactions with heart cells during different stress conditions. This could lead to new therapeutic strategies to prevent heart failure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for cardiovascular diseases or those experiencing early signs of heart stress.
Not a fit: Patients with established heart failure or those who do not have any cardiovascular risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent heart failure by targeting immune mechanisms involved in cardiac remodeling.
How similar studies have performed: Other research has shown promising results in understanding immune cell roles in heart disease, suggesting that this approach could lead to significant advancements.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Van Berlo, Johannes (Jop) — University of Minnesota
- Study coordinator: Van Berlo, Johannes (Jop)
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.