How immature neutrophils contribute to inflammation in obesity
Official title: Immature neutrophil migration promotes inflammation during obesity
Funded at Columbia University Health Sciences · NIH-11071091 · Data updated 2026-11-12
This study is looking at how certain immune cells in the bone marrow change when someone is obese, and how these changes might lead to ongoing inflammation, with the hope of finding new ways to help manage inflammation related to obesity.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | December 24, 2024 |
| Project end | March 14, 2025 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 1F31DK142531-01 |
| Project ID | NIH-11071091 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are obese and may be experiencing related metabolic issues.
✕Less likely to help
Patients who are not obese or do not have related metabolic conditions may not benefit from this research.
What this research studies
This research investigates the role of immature neutrophils in promoting inflammation associated with obesity. It focuses on understanding how obesity alters the behavior of hematopoietic stem and progenitor cells in the bone marrow, leading to an increase in myeloid cells that contribute to chronic inflammation. By using advanced techniques like single-cell RNA sequencing, the study aims to uncover the mechanisms behind these changes and their long-term effects on metabolic health. The findings could help identify new therapeutic targets for managing obesity-related inflammation.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce inflammation and improve metabolic health in individuals with obesity.
How similar studies have gone: Previous research has shown that targeting inflammation can improve metabolic markers in obese individuals, indicating potential success for similar approaches.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Waterbury, Quin Thomas — Columbia University Health Sciences
- Study coordinator: Waterbury, Quin Thomas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.