How IL-10 changes mast cells that drive food and other allergic reactions
Differential regulation of mast cell-mediated allergic responses by IL-10
This research looks at how the immune signal IL-10 alters mast cells that cause food allergy and other allergic reactions to help find better ways to prevent severe responses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Storrs NIH-funded |
| Lab location | 1 site (Storrs-Mansfield, United States) |
| Project ID | NIH-11324489 on NIH RePORTER |
What this research studies
Researchers will study how IL-10 affects mast cell growth, types, and activity that trigger IgE and non-IgE food allergies using laboratory cells and animal models. They will compare responses to different kinds of allergens and test whether IL-10 produced by different cell types causes distinct mast cell behaviors. The project maps the cellular signals that make mast cells more likely to cause swelling, hives, or anaphylaxis. Results are intended to point to new targets to calm or block overactive mast cells in people with food allergy.
Who could benefit from this research
Good fit: People with food allergies, especially those with a history of severe reactions or anaphylaxis, are the patients most directly connected to this research.
Not a fit: People without allergic disease or whose conditions are not driven by mast cells are unlikely to see direct benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could identify new ways to calm or block mast cells and reduce severe food-allergic reactions like anaphylaxis.
How similar studies have performed: Previous lab and animal studies have shown IL-10 can expand and activate mast cells and worsen allergic responses, but the detailed mechanisms and relevance to humans are still being worked out.
Where this research is happening
Storrs-Mansfield, United States
- University of Connecticut Storrs — Storrs-Mansfield, United States (Active)
Researchers
- Principal investigator: Mathias, Clinton B — University of Connecticut Storrs
- Study coordinator: Mathias, Clinton B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.