How IL-10 affects allergic responses in mast cells
Official title: Differential regulation of mast cell-mediated allergic responses by IL-10
Funded at University of Connecticut Storrs · NIH-10987048 · Data updated 2026-11-12
This study is looking at how a substance called IL-10 affects certain immune cells that play a big role in food allergies, with the hope of finding new ways to help manage allergic reactions and keep you safe.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Storrs NIH-funded |
| Lab location | 1 site (Storrs-Mansfield, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $408,570 |
| NIH project number | 5R01AI167884-03 |
| Project ID | NIH-10987048 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with food allergies, particularly those experiencing IgE-mediated or non-IgE-mediated allergic responses.
✕Less likely to help
Patients without food allergies or those whose allergic responses are not mediated by mast cells may not benefit from this research.
What this research studies
This research investigates the role of the cytokine IL-10 in regulating mast cells, which are crucial in allergic responses, particularly to food allergens. It aims to understand how IL-10 influences mast cell growth, activation, and their response to different allergens. By examining the mechanisms behind IL-10's effects, the research seeks to clarify how it can either promote or suppress allergic reactions. This could lead to new insights into managing food allergies and anaphylaxis.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for food allergies and potentially reduce the severity of allergic reactions.
How similar studies have gone: Other research has shown promising results in understanding the role of cytokines in allergic responses, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Connecticut Storrs
Storrs-Mansfield, United States Active
Researchers
- Principal investigator: Mathias, Clinton B — University of Connecticut Storrs
- Study coordinator: Mathias, Clinton B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.