How IGF-1 affects brain cell energy and health as we age
IGF-1 Regulation of Astrocyte Mitochondrial Metabolism and Redox Homeostasis in Brain Aging
This study is looking at how a protein called IGF-1 affects the energy use and health of brain cells as we get older, which could help us understand more about learning and memory, and it’s designed to help a new researcher learn more about brain health for everyone as they age.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-10462512 on NIH RePORTER |
What this research studies
This research investigates the role of IGF-1 in regulating the energy metabolism and oxidative balance of brain cells called astrocytes, particularly as the brain ages. By combining laboratory techniques that study cell metabolism with in vivo approaches, the research aims to uncover how these processes influence learning and memory. The project also focuses on training a new investigator in the field of aging, ensuring that they gain the necessary skills and knowledge to contribute to this important area of research. Patients may benefit from insights gained about brain health and cognitive function as they age.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who may be experiencing cognitive decline or are interested in brain health as they age.
Not a fit: Patients with acute neurological conditions or those not experiencing age-related cognitive changes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for maintaining cognitive function and brain health in aging individuals.
How similar studies have performed: Previous research has shown promising results in understanding the role of IGF-1 in brain health, suggesting that this approach could yield valuable insights.
Where this research is happening
Oklahoma City, United States
- University of Oklahoma Hlth Sciences Ctr — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Logan, Sreemathi — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Logan, Sreemathi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.