How IgE antibodies affect health and allergy
Role of IgE in Homeostasis and Disease
Researchers will look at what IgE antibodies bind to and how those bindings relate to allergies and normal immune protection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11249239 on NIH RePORTER |
What this research studies
This project uses a new lab tool that makes IgE easier to collect and purify so researchers can screen many possible targets that IgE might recognize. The team will compare the set of antigens bound by IgE with those bound by other antibodies like IgG during normal health and after infection. By mapping which targets are unique to IgE or conserved across conditions, they hope to learn which bindings drive harmful allergic reactions versus helpful immune roles. The work is laboratory-based antibody profiling using high-throughput screening enabled by genetic tools.
Who could benefit from this research
Good fit: Ideal participants would be people with IgE-mediated allergic conditions (for example food allergy, allergic rhinitis, or atopic dermatitis) or healthy volunteers willing to give blood samples.
Not a fit: People with non–IgE-driven conditions (such as some forms of asthma or food intolerance that are not antibody mediated) may not directly benefit.
Why it matters
Potential benefit: If successful, this work could reveal new targets for allergy tests or treatments by showing which antigens trigger harmful IgE responses.
How similar studies have performed: Antigen-profiling has been informative for other antibody types like IgG, but broadly mapping IgE targets is relatively new and the team has promising preliminary data.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Medzhitov, Ruslan — Yale University
- Study coordinator: Medzhitov, Ruslan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.