How Ig-fold (immune-type) membrane proteins interact, revealed with nanobody tools
Mapping the Dynamic Interactome of Ig-fold Membrane Proteins Using Nanobody-Based Tools
['FUNDING_OTHER'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11259122
This project builds tiny nanobody tools to reveal how immune-type membrane proteins interact in cells, aiming to help people with cancer and neurodegenerative diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11259122 on ClinicalTrials.gov |
What this research studies
Researchers will engineer camelid-derived nanobodies and combine them with light-activated chemistry to tag nearby proteins in living cells. They will use proximity labeling and mass spectrometry to capture transient and low-abundance interactions of Ig-fold membrane proteins under physiological conditions. The team will focus on underexplored membrane targets linked to cancer and neurodegeneration to map their interaction networks over time. Results are intended to point to signaling pathways and possible targets for future therapies.
Who could benefit from this research
Good fit: People with cancers or degenerative neurologic disorders, or those willing to provide samples or participate in future translational work, are the most likely to be relevant.
Not a fit: Patients without cancer or neurodegenerative conditions or those seeking immediate clinical treatments are unlikely to benefit directly from this basic lab-focused project.
Why it matters
Potential benefit: If successful, this work could reveal new therapeutic targets and improve understanding of membrane protein signaling relevant to cancer and neurodegenerative disease treatment.
How similar studies have performed: Proximity proteomics and nanobody tools have shown promise in related protein-mapping work, but applying them specifically to Ig-fold membrane protein interactomes is a newer and evolving approach.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHI, YI — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: SHI, YI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, Degenerative Neurologic Disorders, Disease, Disorder