How hypertension and a high-fat diet affect memory in older women using estradiol.
Impact of hypertension and high-fat diet on mechanisms by which estradiol affects the hippocampal memory system.
['FUNDING_P01'] · TULANE UNIVERSITY OF LOUISIANA · NIH-11032846
This study is looking at how high blood pressure and a fatty diet affect the way a hormone called estradiol helps with memory in older women, especially in relation to aging and Alzheimer's, to better understand how heart health can influence memory improvement.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TULANE UNIVERSITY OF LOUISIANA (nih funded) |
| Locations | 1 site (NEW ORLEANS, UNITED STATES) |
| Trial ID | NIH-11032846 on ClinicalTrials.gov |
What this research studies
This research investigates how hypertension and a high-fat diet influence the effects of estradiol on memory in the hippocampus, a brain region crucial for memory and often affected by aging and Alzheimer's disease. The study aims to understand the relationship between cardiometabolic health and the effectiveness of estradiol treatment in improving memory function in aging females. By examining individual differences in response to estradiol, the research seeks to clarify how these factors may disrupt the neuroprotective benefits of estrogen. Participants may undergo assessments related to their cardiovascular health and memory performance.
Who could benefit from this research
Good fit: Ideal candidates for this research are women aged 65 and older who are experiencing memory issues and have conditions related to hypertension or high-fat diet.
Not a fit: Patients who are younger than 65 or do not have hypertension or related metabolic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved hormone therapies that enhance memory function in older women, particularly those with hypertension or obesity.
How similar studies have performed: Previous research has shown promising results regarding the neuroprotective effects of estrogens, but this specific approach examining cardiometabolic factors is relatively novel.
Where this research is happening
NEW ORLEANS, UNITED STATES
- TULANE UNIVERSITY OF LOUISIANA — NEW ORLEANS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DANIEL, JILL M — TULANE UNIVERSITY OF LOUISIANA
- Study coordinator: DANIEL, JILL M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.