How hypertension affects COVID-19 outcomes through platelet interactions with the virus
Hypertension augmented COVID-19 through renin-induced internalization of platelet-ACE2 / SARS-Cov-2 complexes
This study is looking at how high blood pressure affects people with COVID-19, especially how the virus interacts with blood platelets, which could lead to serious problems like blood clots; it's for anyone interested in understanding how these conditions are connected and how we might improve treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10899674 on NIH RePORTER |
What this research studies
This research investigates the relationship between hypertension and COVID-19 outcomes, focusing on how the virus interacts with platelets in the blood. It explores the role of ACE2, a receptor for SARS-Cov-2, which is found on platelets and how this interaction may lead to complications such as blood clotting and multi-organ issues. The study employs advanced techniques to analyze platelet behavior and the mechanisms by which hypertension exacerbates COVID-19 severity. By understanding these processes, the research aims to identify potential therapeutic targets to improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with hypertension who have contracted COVID-19.
Not a fit: Patients without hypertension or those who have not contracted COVID-19 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for COVID-19 patients with hypertension, potentially reducing severe complications and mortality.
How similar studies have performed: Previous research has indicated that understanding the role of platelets in viral infections can lead to significant advancements in treatment strategies, suggesting a promising avenue for this investigation.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Mcintyre, Thomas M — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Mcintyre, Thomas M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.